We’d all like to see a procedure that can easily and permanently sterilize a male dog with no complications or side effects. In the past, surgery was the most frequently used treatment option in the United States. There are, however, now substitutes available, such as Zeuterin. It is the only non-surgical method of neutering dogs aged 3 to 10 months that has been approved by the US Food and Drug Administration.

It permanently sterilizes male dogs (between the ages of three and ten months) without requiring surgery. Continue to educate yourself in order to determine whether “zeutering” is a better option.

Can you neuter a dog without surgery?

Neuter dog without surgery

We’d all like to see a simple and permanent sterilization procedure for male dogs that is free of complications or side effects. In the past, surgery was the most frequently used treatment option in the United States.

I was holding a syringe containing an exciting new product called Zeuterin, which permanently sterilizes male dogs (three to ten months of age) without surgery. Will “zeutering” prove to be the superior option? I attended a training session to gain additional knowledge.

Zeuterin is a combination of zinc gluconate and arginine that is injected through a needle into the center of each of a young dog’s testicles. The compound diffuses throughout the testes, causing permanent and irreversible fibrosis and preventing the dog from producing new sperm. Once the sperm in the testicles has been cleared, the dog will be sterile (which will take several weeks).

The procedure involves the use of an extremely fine needle and is virtually painless. There is no need to sedate the dog. The injection could theoretically be given to a calm dog that has been “zeutered” by an experienced veterinarian without the dog is sedated.

Sedation, on the other hand, is a very good idea in practice: if the dog moves during the procedure, complications may occur, and dogs who have been zeutered should receive a small “Z” tattoo on the groin area to identify them as zeutered – and tattoos require sedation.

The dog’s testicles may briefly swell following the injection. Typically, they then atrophy, shrinking to the point where they are no longer visible.

However, for dogs with visible testicles, determining whether they are intact or not can be challenging. Naturally, this is the purpose of the “Z” tattoo – and the company that creates it also sells “I’m Zeutered!” T-shirts for owners who wish to avoid glares from canine-testicle-averse onlookers at the dog park.

What other methods are available for neutering a dog?

The pandemic of COVID-19 has had a global impact on healthcare, including veterinary care for pets. Numerous veterinary clinics are only open in the event of an emergency, in order to minimize transmission and adhere to shelter-in-place orders.

The American Veterinary Medical Association has asked veterinarians to postpone elective procedures to conserve critical medical supplies for human use. Due to the fact that some veterinarians view pet sterilization as optional, spay/neuter services have declined in popularity. Meanwhile, isolated individuals are adopting new pets at a higher rate than usual. This may result in an increase in unwanted puppy and kitten litters.

The Parsemus Foundation encourages pet owners and veterinarians to weigh the advantages and disadvantages of non-surgical alternatives to spay and neuter in order to sterilize pets and reduce pet overpopulation. Several options are listed below, along with their descriptions:

1. Zeuterin

It is an excellent choice for animal shelters and spay-neuter clinics because dogs can typically be in and out in less than a half-hour. (At the moment, only male dogs are eligible.) From the pet’s perspective, the procedure is likely to be similar to a vaccination.

Clipping the fur is not even necessary. Certain dogs may require only mild sedation, while others may require only restraint. Complications are uncommon and, when they do occur, are typically minor and transient. A study of 40 dogs over a two-year period revealed no long-term complications.

2. The Alliance for Contraception in Cats and Dogs:

 (ACC&D) is urging veterinarians to use megestrol acetate to prevent female cats from going into estrus. It is taken orally and can be obtained from a compounding pharmacy. While this is a temporary measure, it adheres to social distancing and medical supply preservation.

3. Sterilization of dogs, cats, and small animals without surgery

Calcium chloride dihydrate solution is an intramuscular chemical sterilant for male animals. It is available through a compounding pharmacy or in pre-measured doses for on-the-spot mixing. Although the cost is minimal, basic medical supplies are required.

The best results are typically obtained with smaller animals and when experienced veterinarians administer the medication. The Parsemus Foundation can provide additional information (for dogs, cats, and small animals).

4. Hormone-free sterilization

While many pet owners are unable to sterilize their animals until social distancing restrictions are lifted, now is an excellent time to learn more about hormone-free sterilization options. The ovaries and testicles are removed during traditional spay and neuter procedures, depriving the pet of natural hormones.

Recent research indicates that an imbalance of hormones is associated with a variety of serious health problems. Hormone-sparing procedures such as hysterectomy or vasectomy sterilize the pet while maintaining normal hormone levels. Learn more about these options for female and male dogs so that you and your veterinarian can discuss the best course of action for your dog once veterinary clinics are fully operational.

How are a zeuter and neuter different?

Neuter dog without surgery

Zeutering has a number of obvious advantages. Due to the inherent risk associated with general anesthesia, avoiding it is unquestionably a good thing. And why would you want to avoid surgically removing a dog’s organs if possible?

As with any medical procedure, Zeuterin may cause adverse reactions. Certain dogs may experience pain for several days to a week following the procedure, and some may vomit.

If the compound is not injected correctly – if some of it comes into contact with the scrotal skin instead of the testicular center – the testicular skin can become irritated and ulcerated. In severe cases, a dog’s entire scrotum may need to be removed surgically, which is a more invasive procedure than a simple castration.

Naturally, surgery carries a risk of complications, such as surgical site infections or fluid accumulation in the empty scrotum (known as a seroma).

There is, however, another critical distinction between surgical neutering and zeutering, and it concerns testosterone. Your attitude toward that hormone may have an effect on the procedure you choose for your next male puppy!

How are spay and neutering surgeries performed?

In Females:

An incision is made in the abdomen (tummy) and the ovaries and womb are carefully tied off and removed (with dissolvable stitches).

In Males:

At the base of the penis, a small incision is made to allow for the tie-off and removal of each testicle (using dissolvable stitches). If your dog is a cryptorchid, the operation may be more challenging (one or both testicles have not dropped). On the other hand, retained testicles must be removed, as they can cause serious complications if left alone.

Depending on the type of stitches used by your veterinarian, you may or may not be able to see the stitches on the outside.

It is necessary to adhere to the established procedure.

When your dog awakens from anesthesia, he or she will be monitored by a veterinarian and/or a vet nurse. They will then be recuperated in a warm, comfortable kennel. While the majority of dogs can be returned to their owners within a few hours of surgery, some require additional monitoring.

What are the rehabilitation, in-home care, and routine physical examinations?

Neuter dog without surgery

When your dog first arrives home, he or she may be sleepy and disoriented. This may last several hours, but as the anesthetic wears off, they will feel significantly better (usually within 24-48 hours).

While it’s natural for your dog to want to run around and be more energetic when they’re feeling better, it’s critical that they rest for 7-10 days to avoid complications with the wound and internal stitches. If necessary, keep your dog on a leash, confine them to a single room, or crate them. Following their recovery from neutering, you must gradually reintroduce them to exercise.

Ensure the safety of the wound

Almost certainly, your dog will be fitted with a protective cone/buster collar to prevent him from licking or nibbling at the wound. If you wish to purchase a soft buster collar or a bodysuit for your dog, consult your veterinarian first.


A follow-up visit is typically required 2-3 days and 7-10 days after surgery to ensure your dog is healing properly and feeling better. Discuss any concerns you have about them with your veterinarian prior to their check-up.

Snatching up

If your dog is wearing dissolvable stitches (which are typically blue/purple in color), they do not need to be removed. If they have non-dissolvable stitches, they will need to have them removed seven to fourteen days after surgery.

What are the risks of spaying or neutering?

In veterinary medicine, neutering/castration or spaying is a very common surgical procedure. Serious complications are extremely unlikely to occur if the dog is healthy and the postoperative care protocol is followed. Although this is a routine procedure, minor to major complications are possible, and you must be aware of them.

  • Prostate and bladder cancer risks are increased:
  • Mixed breeds, Shetland sheepdogs, Scottish terriers, Beagles, English Springer Spaniels, German shorthaired pointers, and West Highland white terriers are all at risk. Consult your veterinarian about the best options if you own one of these breeds.
  •  Weight gain as a result of surgery if the diet is not adjusted properly.
  • Fear aggression may exacerbateif it occurs prior to a thorough assessment of fearful behavior and implementation of a behavioral modification plan.
  •  Rottweilers stand out in particular. There is some evidence that Rottweilers are predisposed to bone cancer following castration (osteosarcoma).

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Top 5 FAQ & Answer on neuter dog without surgery

What are some of the benefits of not neutering your dog?

If your dog is not neutered, he will become agitated if he detects a female in heat up to a mile away.

Is it possible that neutering a dog may result in complications?

Is the operation risky in any way? Neutering is a significant surgical procedure that requires general anesthesia. With any anesthetic, there is always a risk of serious complications, including death. However, with modern anesthetics and monitoring equipment, the risk of complications is extremely low.

Is it true that after neutering dogs, they become less aggressive?

While neutered male dogs exhibit an increase in aggressive behavior immediately after the procedure, neutering can result in significant reductions in aggression over time. Indeed, it has been demonstrated that neutering male dogs over time makes them happier and calmer.

Why would you refuse to neuter your dog?

Neutering is associated with a threefold increase in the risk of hypothyroidism.
• The early neutering of male dogs increases the risk of developing bone cancer. In medium/large and larger breeds, osteosarcoma is common cancer with a poor prognosis.
• Male dogs that have been neutered are more likely to develop additional orthopedic diseases.

How does Zeuterin work?

Male dogs are sterilized without surgery using the drug Zeuterin. ZeuterinTM is a solution of zinc gluconate that can be injected into the testicles of dogs to sterilize them. Zeuterin, alternatively referred to as Zeutering, is a method of neutering that is non-surgical.


Neuter dog without surgery

Pet overpopulation is a global issue, and unplanned litters account for an alarming number of euthanasias in the United States and elsewhere. As a responsible pet owner, you must take steps to avoid unintentional litter.

As a result, neutering a dog is frequently viewed as a necessary component of responsible pet ownership. However, surgery carries a risk of complications, including surgical site infections or fluid accumulation in the empty scrotum (known as a seroma).

Apart from traditional surgical spaying and neutering, there are some safe and painless options for sterilizing pets and reducing pet overpopulation available, such as Zeuterin. It was a top-selling veterinary product last year.

And it is only now beginning to reach its full potential. Zeuterin has been used to control dog populations in areas abandoned following the 2011 earthquake and tsunami in Japan, as well as feral dog populations in the Philippines. Humane dog population control is also a public health issue in these situations, as it protects people from injury and disease.

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